Those are the ones who disbelieve in the verses of their Lord and in [their] meeting Him, so their deeds have become worthless; and We will not assign to them on the Day of Resurrection any weight [i.e., importance].
They are those who disbelieve in the signs of their Lord that prove His oneness and disbelieved in meeting Him, hence their actions became void due to their denial, and so they will not have any value with Allah on the Day of Judgment.